Drug General Information (ID: DDIO49R7JM)
Drug Name			Methotrimeprazine		Drug Info		Alogliptin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cns Agents				Antidiabetic Agents
Structure

Mechanism of Methotrimeprazine-Alogliptin Interaction (Severity Level: Moderate)
Antagonize the effect of antidiabetic agents Click to Show/Hide Mechanism Graph
Drug Name		Methotrimeprazine				Alogliptin
Mechanism 1		Hyperglycemia				Antidiabetic agent
Key Mechanism Factor 1
		Factor Name		Antidiabetic agents
		Factor Description		The hypoglycemic effect of antidiabetes may be reduced, leading to higher blood glucose, increased blood glucose fluctuations, and the possibility of hyperglycemic complications
Mechanism Description		Antagonize the effect of Alogliptin when combined with Methotrimeprazine
Mechanism 2		Hyperglycemic effects				Antidiabetic agent
Key Mechanism Factor 2
		Factor Name		Antidiabetic agents
		Factor Description		The hypoglycemic effect of antidiabetes may be reduced, leading to higher blood glucose, increased blood glucose fluctuations, and the possibility of hyperglycemic complications
Mechanism Description		Antagonize the effect of Alogliptin when combined with Methotrimeprazine

Recommended Action
Management		Close clinical monitoring of glycemic control is recommended following initiation or discontinuation of these drugs, and the dosages of concomitant antidiabetic agents adjusted as necessary. Patients should be advised to notify their physician if their blood glucose is consistently high or if they experience symptoms of severe hyperglycemia such as excessive thirst and increases in the volume or frequency of urination.

References
1	Jori A, Carrara MC "On the mechanism of the hyperglycaemic effect of chlorpromazine." J Pharm Pharmacol 18 (1966): 623-4. [PMID: 4381950]
2	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
3	Product Information. Thorazine (chlorpromazine). SmithKline Beecham, Philadelphia, PA.