Drug General Information (ID: DDIO2E4YUM)
Drug Name			Octreotide		Drug Info		Quinidine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Somatostatin/Somatostatin Analogs				Group I Antiarrhythmics
Structure

Mechanism of Octreotide-Quinidine Interaction (Severity Level: Moderate)
Increased risk of bradycardia Click to Show/Hide Mechanism Graph
Drug Name		Octreotide				Quinidine
Mechanism		Bradycardia				Bradycardia
Key Mechanism Factor 1
		Factor Name		Bradycardia
		Factor Description		Bradycardia is a slow heart rate in which the heart beats less than 60 times per minute. If the heart rate is very slow and the heart is not pumping enough oxygen-rich blood to the body, and you may feel dizzy, very tired or weak, and short of breath.
Mechanism Description		Increased risk of bradycardia by the combination of Octreotide and Quinidine

Recommended Action
Management		Caution is advised if somatostatin analogs are prescribed with agents that exhibit bradycardic effects, including ophthalmic formulations of beta-blockers. Heart rate and blood pressure should be monitored.

References
1	Product Information. Sandostatin (octreotide). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
2	Product Information. Somatuline Depot (lanreotide). Ipsen Inc, Milford, MA.