Details of Drug Interaction | MecDDI

Drug General Information (ID: DDIO1GET9M)
Drug Name			Ziprasidone		Drug Info		Dexbrompheniramine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antipsychotic Agents				Antihistamines
Structure

Mechanism of Ziprasidone-Dexbrompheniramine Interaction (Severity Level: Moderate)
Additive anticholinergic effects Click to Show/Hide Mechanism Graph

Drug Name		Ziprasidone				Dexbrompheniramine
Mechanism		Anticholinergic effects Muscarinic acetylcholine receptor Antagonist				Anticholinergic effects Muscarinic acetylcholine receptor Antagonist
Key Mechanism Factor 1
		Factor Name		Muscarinic acetylcholine receptor M				Structure Sequence
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Click to Show/Hide
Mechanism Description		Additive anticholinergic effects by the combination of Ziprasidone and Dexbrompheniramine

Recommended Action
Management		Caution is advised when agents with anticholinergic properties are combined, particularly in the elderly and those with underlying organic brain disease, who tend to be more sensitive to the central anticholinergic effects of these drugs and in whom toxicity symptoms may be easily overlooked. Patients should be advised to notify their physician promptly if they experience potential symptoms of anticholinergic intoxication such as abdominal pain, fever, heat intolerance, blurred vision, confusion, and/or hallucinations.

References
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