Details of Drug Interaction | MecDDI

Drug General Information (ID: DDINWS54IO)
Drug Name			Meclizine		Drug Info		Tranylcypromine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiallergic Agents				Antidepressants
Structure

Mechanism of Meclizine-Tranylcypromine Interaction (Severity Level: Minor)
Additive anticholinergic effects Click to Show/Hide Mechanism Graph

Drug Name		Meclizine				Tranylcypromine
Mechanism		Anticholinergic effects Muscarinic acetylcholine receptor Antagonist				Anticholinergic effects Monoamine oxidase non-selective Inhibitor
Key Mechanism Factor 1
		Factor Name		Muscarinic acetylcholine receptor M				Structure Sequence
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Click to Show/Hide
Key Mechanism Factor 2
		Factor Name		Monoamine oxidase				Structure Sequence
		Protein Family		Flavin monoamine oxidase family
		Protein Function		Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:20493079, PubMed:8316221, PubMed:18391214, PubMed:24169519). Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity). Click to Show/Hide
Mechanism Description		Additive anticholinergic effects by the combination of Meclizine and Tranylcypromine

References
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