Drug General Information (ID: DDINU7O94I)
Drug Name			Methysergide		Drug Info		Methylergometrine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasoconstrictor Agents				Oxytocics
Structure

Mechanism of Methysergide-Methylergometrine Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Methysergide				Methylergometrine
Mechanism		Risk of vasospastic reactions				Risk of vasospastic reactions
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Methysergide and Methylergometrine

Recommended Action
Management		The concomitant use of two or more 5-HT1 receptor agonists and/or ergotamine-containing or ergot-type medications, or use within 24 hours of each other, is considered contraindicated.

References
1	Product Information. Axert (almotriptan) Pharmacia and Upjohn, Kalamazoo, MI.
2	Product Information. Parlodel (bromocriptine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
3	Product Information. Maxalt (rizatriptan). Merck &amp Co, Inc, West Point, PA.