Details of Drug-Drug Interaction
| Drug General Information (ID: DDINHOV785) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Digoxin | Drug Info | Clorazepic acid | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antiarrhythmic Agents | Anxiolytics/Sedatives/Hypnotics | |||||||
| Structure | |||||||||
| Mechanism of Digoxin-Clorazepic acid Interaction (Severity Level: Moderate) | |||||||||
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| Competitive binding of plasma proteins Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Digoxin | Clorazepic acid | |||||||
| Mechanism | Competition for plasma protein binding sites | Competition for plasma protein binding sites | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Plasma protein binding | ||||||||
| Factor Description | Plasma protein binding refers to the degree of binding of a drug to proteins in the blood, and the lower the degree of binding, the more efficiently the drug can cross cell membranes or diffuse. Plasma protein binding alters the distribution and therapeutic characteristics of the drugs. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Close observation for clinical and laboratory evidence of digoxin toxicity is recommended if these drugs must be used together. Patients should be advised to notify their physician if they experience nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeats. | ||||||||