Details of Drug Interaction

Drug General Information (ID: DDIN9QUV4K)
Drug Name		Tadalafil	Drug Info		Nesiritide	Drug Info
Drug Type	Small molecule			Hormones
Therapeutic Class	Impotence Agents			Recombinant Natriuretic Peptide
Structure

Mechanism of Tadalafil-Nesiritide Interaction (Severity Level: Minor)
Additive hypotensive effects Click to Show/Hide Mechanism Graph

Drug Name	Tadalafil		Nesiritide
Mechanism	Hypotensive effects Prostacyclin receptor Agonist		Antihypertensive agent Guanylate cyclase Agonist
Key Mechanism Factor 1
	Factor Name	Prostacyclin receptor		× Structure Sequence MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
	Gene Name	PTGIR
	Uniprot ID	PI2R_HUMAN
	KEGG Pathway	hsa:5739
	Protein Family	G-protein coupled receptor 1 family
	Protein Function	Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. Click to Show/Hide
Key Mechanism Factor 2
	Factor Name	Guanylate cyclase soluble		Structure Sequence
	Protein Family	Adenylyl cyclase class-4/guanylyl cyclase family
	Protein Function	There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. Activated by nitric oxide in the presence of magnesium or manganese ions. Click to Show/Hide
Mechanism Description	Additive hypotensive effects by the combination of Tadalafil and Nesiritide

References
1	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
2	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.

Details of Drug-Drug Interaction