Drug General Information (ID: DDIN7A4HDC)
Drug Name			Alendronic acid		Drug Info		Parathyroid hormone		Drug Info
Drug Type		Small molecule				Hormones
Therapeutic Class		Bone Density Conservation Agents				Hormone Modulators

Mechanism of Alendronic acid-Parathyroid hormone Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Alendronic acid				Parathyroid hormone
Mechanism		Reduce the therapeutic effects of parathyroid hormone				Parathyroid hormone
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Parathyroid hormone when combined with Alendronic acid

Recommended Action
Management		Concomitant use of parathyroid hormone with alendronate is not recommended.

References
1	Product Information. Fosamax (alendronate). Merck &amp Co, Inc, West Point, PA.
2	Product Information. Natpara (parathyroid hormone). NPS Pharmaceuticals, Bedminster, NJ.