Drug General Information (ID: DDIN385QDX)
Drug Name			Triamterene		Drug Info		Digoxin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diuretics				Antiarrhythmic Agents
Structure

Mechanism of Triamterene-Digoxin Interaction (Severity Level: Minor)
Decreased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Triamterene				Digoxin
Mechanism		Decrease the extrarenal clearance of digoxin				Digoxin
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased renal excretion of Digoxin caused by Triamterene

References
1	Brown DD, Dormois JC, Abraham GN, et al "Effect of furosemide on the renal excretion of digoxin." Clin Pharmacol Ther 20 (1976): 395-400. [PMID: 975715]
2	Malcolm AD, Leung FY, Fuchs JC, Duarte JE "Digoxin kinetics during furosemide administration." Clin Pharmacol Ther 21 (1977): 567-74. [PMID: 870271]
3	Marcus FI "Pharmacokinetic interactions between digoxin and other drugs." J Am Coll Cardiol 5 (1985): a82-90. [PMID: 2985676]