Drug General Information (ID: DDIN18VXBT)
Drug Name			Dexlansoprazole		Drug Info		Ledipasvir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Proton Pump Inhibitors				Antiviral Agents
Structure

Mechanism of Dexlansoprazole-Ledipasvir Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Dexlansoprazole				Ledipasvir
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Ledipasvir due to altered gastric pH caused by Dexlansoprazole

Recommended Action
Management		Proton-pump inhibitors at doses comparable to omeprazole 20 mg or lower should only be administered either simultaneously with or up to 2 hours after ledipasvir-sofosbuvir under fasted conditions. Some authorities advise against administering proton pump inhibitors before ledipasvir-containing products however, a timeframe of dosage separation has not been specified.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.