Drug General Information (ID: DDIMZCD97I)
Drug Name			Doxycycline		Drug Info		Hydrochlorothiazide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinflammatory Agents				Diuretics
Structure

Mechanism of Doxycycline-Hydrochlorothiazide Interaction (Severity Level: Minor)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Doxycycline				Hydrochlorothiazide
Mechanism		Decrease in renal function due to combination with diuretic				Diuretic
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Doxycycline and Hydrochlorothiazide

Recommended Action
Management		Usually, no clinical intervention is necessary, unless decreases in renal function occur. If renal function deteriorates, discontinuation of one or both agents may be necessary.

References
1	Garty M, Hurwitz A "Effect of cimetidine and antacids on gastrointestinal absorption of tetracycline." Clin Pharmacol Ther 28 (1980): 203-7. [PMID: 7398187]
2	Alexander MR "Tetracycline and rises in urea nitrogen." JAMA 221 (1972): 713-4
3	Jick H, Slone D, Shapiro S, et al "Tetracycline and drug-attributed rises in blood urea nitrogen: a report from the Boston Collaborative Drug Surveillance Program." JAMA 220 (1972): 377-9