Drug General Information (ID: DDIMPO7JSX)
Drug Name			Nabumetone		Drug Info		Vancomycin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Nsaids/Analgesics				Antiinfective Agents
Structure

Mechanism of Nabumetone-Vancomycin Interaction (Severity Level: Moderate)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Nabumetone				Vancomycin
Mechanism		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Nabumetone and Vancomycin

Recommended Action
Management		Caution is recommended in patients receiving ketorolac or other NSAIDs in combination with IV vancomycin, particularly in patients with preexisting risk factors for nephrotoxicity. Renal function and vancomycin therapeutic drug monitoring is recommended according to local policies and protocols. The dose and duration of concomitant NSAID therapy should also be minimized where possible.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Hazlewood KA, Brouse SD, Pitcher WD, Hall RG "Vancomycin-associated nephrotoxicity: grave concern or death by character assassination?" Am J Med 123 (2010): 182.e1-7. [PMID: 20103028]
4	Murray RP, Watson RC "Acute renal failure and gastrointestinal bleed associated with postoperative toradol and vancomycin." Orthopedics 16 (1993): 1361-3. [PMID: 8108288]
5	Product Information. Toradol (ketorolac). Roche Laboratories, Nutley, NJ.
6	Product Information. Vancocin (vancomycin). Lilly, Eli and Company, Indianapolis, IN.