Details of Drug-Drug Interaction
| Drug General Information (ID: DDIMI7VZ8T) | |||||||||
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| Drug Name | Tadalafil | Drug Info | Eprosartan | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Impotence Agents | Antihypertensive Agents | |||||||
| Structure | |||||||||
| Mechanism of Tadalafil-Eprosartan Interaction (Severity Level: Minor) | |||||||||
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| Additive hypotensive effects Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Tadalafil | Eprosartan | |||||||
| Mechanism |
Hypotensive effects Prostacyclin receptor Agonist |
Antihypertensive agent Angiotensin II receptor Antagonist |
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| Key Mechanism Factor 1 | |||||||||
| Factor Name | Prostacyclin receptor |
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Structure
Sequence
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
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| Gene Name | PTGIR | ||||||||
| Uniprot ID | PI2R_HUMAN | ||||||||
| KEGG Pathway | hsa:5739 | ||||||||
| Protein Family | G-protein coupled receptor 1 family | ||||||||
| Protein Function |
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
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| Key Mechanism Factor 2 | |||||||||
| Factor Name | Angiotensin II receptor | Structure Sequence | |||||||
| Protein Family | G-protein coupled receptor 1 family | ||||||||
| Protein Function |
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.; (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.
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| Mechanism Description |
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| References | |||||||||||||||||||
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| 1 | Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN. | ||||||||||||||||||
| 2 | Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA. | ||||||||||||||||||