Drug General Information (ID: DDIMHWIAU1)
Drug Name			Caffeine		Drug Info		Cycloserine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Antiinfective Agents
Structure

Mechanism of Caffeine-Cycloserine Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Caffeine				Cycloserine
Mechanism		CNS stimulant effects				CNS stimulant effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Caffeine and Cycloserine

Recommended Action
Management		Caution is advised when cycloserine or terizidone is used with caffeine. Consumption of certain beverages or stimulants with very high caffeine levels should be avoided as a precautionary measure.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".