Drug General Information (ID: DDIMF416OA)
Drug Name			Cariprazine		Drug Info		Lithium carbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Atypical Antipsychotics				Antimanic Agents
Structure

Mechanism of Cariprazine-Lithium carbonate Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Cariprazine				Lithium carbonate
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Cariprazine and Lithium carbonate

Recommended Action
Management		Close monitoring for central nervous system adverse effects is recommended when lithium is used with neuroleptic agents. Dosage adjustments or discontinuation of one or both drugs may be necessary if an interaction is suspected.

References
1	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
2	Swanson CL, Price WA, Mcevoy JP "Effects of concomitant risperidone and lithium treatment." Am J Psychiatry 152 (1995): 1096. [PMID: 7540798]
3	Goldman SA "FDA medwatch report: lithium and neuroleptics in combination: the spectrum of neurotoxicity." Psychopharmacol Bull 32 (1996): 299-309. [PMID: 8961772]