Drug General Information (ID: DDIME0L9RA)
Drug Name			Remifentanil		Drug Info		Opium		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anxiolytics/Sedatives/Hypnotics				Narcotic Analgesics

Mechanism of Remifentanil-Opium Interaction (Severity Level: Moderate)
Additive cardiorespiratory depression effects Click to Show/Hide Mechanism Graph
Drug Name		Remifentanil				Opium
Mechanism		Cardiorespiratory depression effects				Cardiorespiratory depression effects
Key Mechanism Factor 1
		Factor Name		Cardiorespiratory depression effects
		Factor Description		Cardiorespiratory depression is a reduction or inhibition of the normal function of the heart and lungs. The heart and lungs are the most important organs of the body's circulatory system, and when excessively depressed may result in decreased heart rate, decreased blood pressure, heart failure, slowed breathing (little to no visible chest movement), apnea, narrowed or pinpoint pupils, and seizures.
Mechanism Description		Additive cardiorespiratory depression effects by the combination of Remifentanil and Opium

Recommended Action
Management		The dosage of alfentanil, remifentanil, or sufentanil may need to be decreased in patients who have received large doses of narcotics.

References
1	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.