| Management |
Concomitant use of certain desmopressin products with loop diuretics or systemic or inhaled corticosteroids is considered contraindicated. Please consult individual product labeling for specific recommendations. Caution is advised when coadministration is required. Serum electrolytes, especially sodium, as well as BUN and creatinine should be monitored regularly and as often as clinically appropriate based on individual risk factors. Patients should be advised to seek medical attention if they develop signs and symptoms of water intoxication or hyponatremia such as anorexia, nausea, vomiting, headache, malaise, lethargy, irritability, difficulty concentrating, memory impairment, confusion, weakness, muscle spasm, unsteadiness (which may lead to falls), anuria, and weight gain. Severe hyponatremia can be life-threatening if it is not promptly diagnosed and treated therefore, early treatment is important to help prevent progression to seizures, coma, respiratory arrest, and death. |
