Drug General Information (ID: DDILY84ZBE)
Drug Name			Hyoscyamine		Drug Info		Ketoconazole		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Antifungal Agents
Structure

Mechanism of Hyoscyamine-Ketoconazole Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Hyoscyamine				Ketoconazole
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Ketoconazole due to altered gastric pH caused by Hyoscyamine

Recommended Action
Management		Anticholinergic agents should be administered at least 2 hours after ketoconazole.

References
1	Fleseriu M, Auchus R, Pivonello R, et al. "Levoketoconazole: a novel treatment for endogenous Cushing's syndrome.".
2	Product Information. Nizoral (ketoconazole). Janssen Pharmaceutica, Titusville, NJ.
3	Product Information. Recorlev (levoketoconazole). Xeris Pharmaceuticals Inc, Chicago, IL.