Drug General Information (ID: DDILVGAXOY)
Drug Name			Enflurane		Drug Info		Norepinephrine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anesthetics				Vasoconstrictor Agents
Structure

Mechanism of Enflurane-Norepinephrine Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Enflurane				Norepinephrine
Mechanism		Increase the arrhythmogenic effects of catecholamines				Catecholamines
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Norepinephrine and Enflurane

Recommended Action
Management		This combination should be avoided or used very cautiously. If a halogenated anesthetic and norepinephrine must be used together, very low doses of norepinephrine concentrations are recommended and the patient's hemodynamic status should be closely monitored.

References
1	Cooke JE "Drug interactions in anesthesia." Clin Plast Surg 12 (1985): 83-9.[PMID: 2858281]
2	Smith RB "Drug interactions and drug reactions." Otolaryngol Clin North Am 14 (1981): 615-29.[PMID: 7029414]
3	Product Information. Fluothane (halothane). Wyeth-Ayerst Laboratories, Philadelphia, PA.