Details of Drug-Drug Interaction
| Drug General Information (ID: DDILV4XEIN) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Dexlansoprazole | Drug Info | Rilpivirine | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Proton Pump Inhibitors | Antiviral Agents | |||||||
| Structure | |||||||||
| Mechanism of Dexlansoprazole-Rilpivirine Interaction (Severity Level: Major) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Altered gastric pH Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Dexlansoprazole | Rilpivirine | |||||||
| Mechanism | Gastric alkalinizer | Gastric pH sensitive | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Gastric pH | ||||||||
| Factor Description | The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, concomitant use of rilpivirine with proton pump inhibitors is considered contraindicated. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ. | ||||||||||||||||||