Drug General Information (ID: DDILP21JA4)
Drug Name			Prednicarbate (topical)		Drug Info		Pramlintide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinflammatory Agents				Antidiabetic Agents
Structure

Mechanism of Prednicarbate (topical)-Pramlintide Interaction (Severity Level: Minor)
Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Drug Name		Prednicarbate (topical)				Pramlintide
Mechanism 1		Hyperglycemia				Antidiabetic agent
Key Mechanism Factor 1
		Factor Name		Antihypertensive agents
		Factor Description		The hypotensive effect of antihypertensive agents may be reduced, leading to higher blood pressure, increased blood pressure fluctuations, and possible cardiovascular damage.
Mechanism Description		Antagonize the effect of Pramlintide when combined with Prednicarbate (topical)
Mechanism 2		Hyperglycemic effects				Antidiabetic agent
Key Mechanism Factor 2
		Factor Name		Antihypertensive agents
		Factor Description		The hypotensive effect of antihypertensive agents may be reduced, leading to higher blood pressure, increased blood pressure fluctuations, and possible cardiovascular damage.
Mechanism Description		Antagonize the effect of Pramlintide when combined with Prednicarbate (topical)

References
1	Seale JP, Compton MR "Side-effects of corticosteroid agents." Med J Aust 144 (1986): 139-42. [PMID: 3511355]
2	Product Information. Psorcon (diflorasone topical). Rhone-Poulenc Rorer, Collegeville, PA.
3	Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim. [PMID: 4682644]