Details of Drug-Drug Interaction
| Drug General Information (ID: DDILNIQ682) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Methotrexate | Drug Info | Mercaptopurine | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antimetabolites | Antineoplastics | |||||||
| Structure | |||||||||
| Mechanism of Methotrexate-Mercaptopurine Interaction (Severity Level: Minor) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph | |||||||||
| Drug Name | Methotrexate | Mercaptopurine | |||||||
| Mechanism | Inhibit the hepatic metabolism of thiopurines | Thiopurines | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Pharmacokinetics | ||||||||
| Factor Description | Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects. | ||||||||
| Mechanism Description |
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| References | |||||||||||||||||||
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| 1 | Balis FM, Holcenberg JS, Zimm S, et al "The effect of methotrexate on the bioavailability of oral 6-mercaptopurine." Clin Pharmacol Ther 41 (1987): 384-7. [PMID: 3470165] | ||||||||||||||||||