Drug General Information (ID: DDILNH5R19)
Drug Name			Fluorouracil		Drug Info		Diroximel fumarate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Immunosuppressive Agents				Selective Immunosuppressants
Structure

Mechanism of Fluorouracil-Diroximel fumarate Interaction (Severity Level: Moderate)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Fluorouracil				Diroximel fumarate
Mechanism		Immunosuppressive effects				Immunosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Fluorouracil and Diroximel fumarate

Recommended Action
Management		The safety and efficacy of monomethyl fumarate, dimethyl fumarate, or diroximel fumarate in combination with other immunosuppressive or myelosuppressive agents have not been evaluated. Until further information is available, concomitant use should be avoided if possible.

References
1	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.