Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDILN2ICYX)
  Drug Name Linezolid Drug Info Tetryzoline (nasal) Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antibiotics Alpha-Adrenergic Agonists
  Structure

 Mechanism of Linezolid-Tetryzoline (nasal) Interaction (Severity Level: Major)
     Additive hypertensive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Linezolid Tetryzoline (nasal)
      Mechanism Hypertensive effects
Monoamine oxidase non-selective  Inhibitor 		Hypertensive effects
Alpha-1 adrenergic receptor  Agonist
      Key Mechanism Factor 1
Factor Name Monoamine oxidase Structure Sequence
Protein Family Flavin monoamine oxidase family
Protein Function
Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:20493079, PubMed:8316221, PubMed:18391214, PubMed:24169519). Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity).
    Click to Show/Hide
      Key Mechanism Factor 2
Factor Name Adrenergic receptor alpha-1 Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
    Click to Show/Hide
      Mechanism Description
  • Additive hypertensive effects by the combination of Linezolid and Tetryzoline (nasal) 

Recommended Action
      Management Concomitant use of tetrahydrozoline nasal formulations with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, methylene blue, procarbazine) is considered contraindicated by the manufacturers.

References
1 Product Information. Matulane (procarbazine). Roche Laboratories, Nutley, NJ.
2 Product Information. Tyzine (tetrahydrozoline). Kenwood Laboratories, Fairfield, NJ.
3 Product Information. Zyvox (linezolid) Pharmacia and Upjohn, Kalamazoo, MI.