Drug General Information (ID: DDILMAITCN)
Drug Name			Mefloquine		Drug Info		Metoclopramide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antimalarial Agents				Antiemetics
Structure

Mechanism of Mefloquine-Metoclopramide Interaction (Severity Level: Minor)
Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Drug Name		Mefloquine				Metoclopramide
Mechanism		Absorption is influenced by gastrointestinal motility				Increase gastrointestinal motility
Key Mechanism Factor 1
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Mefloquine due to GI dynamics variation caused by Metoclopramide

References
1	Bangchang KN, Karbwang J, Bunnag D, et al "The effect of metoclopramide on mefloquine pharmacokinetics." Br J Clin Pharmacol 32 (1991): 640-1. [PMID: 1954082]