Drug General Information (ID: DDILIDFJOB)
Drug Name			Warfarin		Drug Info		Simeprevir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticoagulants				Antiinfective Agents
Structure

Mechanism of Warfarin-Simeprevir Interaction (Severity Level: Moderate)
Antagonize the effect of antithrombotic agents Click to Show/Hide Mechanism Graph
Drug Name		Warfarin				Simeprevir
Mechanism		Vitamin K antagonist				Interference with hepatic synthesis of vitamin K-dependent coagulation factors
Key Mechanism Factor 1
		Factor Name		Antithrombotic agents
		Factor Description		The beneficial effects of antithrombotic agents are reduced, leading to an increased risk of thromboembolism, stroke and/or myocardial infarction.
Mechanism Description		Antagonize the effect of Warfarin when combined with Simeprevir

Recommended Action
Management		The INR should be monitored more closely following initiation or discontinuation of a direct-acting HCV antiviral agent, and the dosage of vitamin K antagonist adjusted if necessary.

References
1	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
5	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
6	Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
7	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.