Drug General Information (ID: DDILGZ6I5W)
Drug Name			Trimethobenzamide		Drug Info		Apomorphine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticholinergic Agents/Antiemetics				Dopaminergic Antiparkinsonism Agents
Structure

Mechanism of Trimethobenzamide-Apomorphine Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Trimethobenzamide				Apomorphine
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Trimethobenzamide and Apomorphine

Recommended Action
Management		Monitoring for potentially excessive or prolonged CNS depression is recommended. Patients should be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them. If patients experience increased episodes of falling asleep during normal daily activities, they should avoid driving and other potentially hazardous activities until they have contacted their physician.

References
1	Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.
2	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
3	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]