Drug General Information (ID: DDILDCSKOW)
Drug Name			Dicyclomine		Drug Info		Chlorothiazide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticholinergic Agents				Antihypertensive Agents
Structure

Mechanism of Dicyclomine-Chlorothiazide Interaction (Severity Level: Minor)
Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Drug Name		Dicyclomine				Chlorothiazide
Mechanism		Decrease gastrointestinal motility				Absorption is influenced by gastrointestinal motility
Key Mechanism Factor 1
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Chlorothiazide due to GI dynamics variation caused by Dicyclomine

References
1	Beermann B, Groschinsky-Grind M "Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline." Eur J Clin Pharmacol 13 (1978): 385-7. [PMID: 668798]
2	Shukla UA, Pittman KA, Barbhaiya RH. Pharmacokinetic interactions of cefprozil with food, propantheline, metoclopramide, and probenecid in healthy volunteers.?J Clin Pharmacol. 1992;32(8):725-731. [PMID: 1487562]