Drug General Information (ID: DDILCDPUWA)
Drug Name			Digoxin		Drug Info		Salicylic acid (sodium)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Antiinflammatory Agents
Structure

Mechanism of Digoxin-Salicylic acid (sodium) Interaction (Severity Level: Moderate)
Decreased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Digoxin				Salicylic acid (sodium)
Mechanism		Digoxin				Decrease the excretion rate of digoxin
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased renal excretion of Digoxin caused by Salicylic acid (sodium)

Recommended Action
Management		Patients who require concomitant therapy should be monitored for altered pharmacologic effects of digoxin and for increased plasma levels. The digoxin dosage may require adjustment. Patients should be advised to notify their physician if they experience nausea, anorexia, visual changes, slow pulse, or irregular heartbeats.

References
1	Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44. [PMID: 3056649]
2	Finch MB, Johnston GD, Kelly JG, McDevitt DG "Pharmacokinetics of digoxin alone and in the presence of indomethacin therapy." Br J Clin Pharmacol 17 (1984): 353-5
3	Jorgensen HS, Christensen HR, Kampmann JP "Interaction between digoxin and indomethacin or ibuprofen." Br J Clin Pharmacol 31 (1991): 108-10