Details of Drug Interaction | MecDDI

Drug General Information (ID: DDILBCMI8D)
Drug Name			Edrophonium		Drug Info		Echothiophate (ophthalmic)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidotes				Ophthalmic Glaucoma Agents
Structure

Mechanism of Edrophonium-Echothiophate (ophthalmic) Interaction (Severity Level: Moderate)
Additive cholinergic effects Click to Show/Hide Mechanism Graph

Drug Name		Edrophonium				Echothiophate (ophthalmic)
Mechanism		Cholinergic effects Acetylcholinesterase Inhibitor				Cholinergic effects Acetylcholinesterase Inhibitor
Key Mechanism Factor 1
		Factor Name		Acetylcholinesterase				× Structure Sequence MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
		Gene Name		ACHE
		Uniprot ID		ACES_HUMAN
		KEGG Pathway		hsa:43
		Protein Family		Type-B carboxylesterase/lipase family
		Protein Function		Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis. Click to Show/Hide
Mechanism Description		Additive cholinergic effects by the combination of Edrophonium and Echothiophate (ophthalmic)

Recommended Action
Management		Patients should be monitored for excessive cholinergic effects and worsening of myasthenic symptoms.

References
1	Product Information. Phospholine Iodide (echothiophate iodide ophthalmic). Wyeth Laboratories, Philadelphia, PA.