Drug General Information (ID: DDIL9UGVN0)
Drug Name			Magnesium chloride		Drug Info		Atracurium		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Minerals And Electrolytes				Neuromuscular Blocking Agents
Structure

Mechanism of Magnesium chloride-Atracurium Interaction (Severity Level: Moderate)
Additive neuromuscular blocking effects Click to Show/Hide Mechanism Graph
Drug Name		Magnesium chloride				Atracurium
Mechanism		Potentiates neuromuscular blockade				Neuromuscular blocking agent Neuronal acetylcholine receptor  Antagonist
Key Mechanism Factor 1
		Factor Name		Neuronal acetylcholine receptor				Structure Sequence
		Protein Family		Ligand-gated ion channel (TC 1.A.9) family
		Protein Function		After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.     Click to Show/Hide
Mechanism Description		Additive neuromuscular blocking effects by the combination of Magnesium chloride and Atracurium

Recommended Action
Management		Patients should be closely monitored for excessive or prolonged neuromuscular blockade and ventilatory support should be immediately available.

References
1	Fuchs-Buder T, Wilder-Smith OH, Borgeat A, Tassonyi E "Interaction of magnesium sulphate with vecuronium-induced neuromuscular block." Br J Anaesth 74 (1995): 405-9. [PMID: 7734259]
2	Product Information. Norcuron (vecuronium). Organon, West Orange, NJ.