| Mechanism of Sirolimus-Temsirolimus Interaction
(Severity Level: Major)
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Additive immunosuppressive effects
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| Drug Name |
Sirolimus |
Temsirolimus |
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Mechanism 1
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Immunosuppressive effects |
Immunosuppressive effects |
| Key Mechanism Factor 1 |
| Factor Name |
Immunosuppressive effects |
| Factor Description |
Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal. |
| Mechanism Description |
- Additive immunosuppressive effects by the combination of Sirolimus and Temsirolimus
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Increased risk of nephrotoxicity
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| Drug Name |
Sirolimus |
Temsirolimus |
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Mechanism 2
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Nephrotoxicity |
Nephrotoxicity |
| Key Mechanism Factor 2 |
| Factor Name |
Nephrotoxicity |
| Factor Description |
The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood. |
| Mechanism Description |
- Increased risk of nephrotoxicity by the combination of Sirolimus and Temsirolimus
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Increased risk of other adverse reactions (Unspecific)
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| Drug Name |
Sirolimus |
Temsirolimus |
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Mechanism 3
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Pulmonary toxicity |
Pulmonary toxicity |
| Key Mechanism Factor 3 |
| Factor Name |
Adverse reactions |
| Factor Description |
An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly. |
| Mechanism Description |
- Increased risk of adverse reactions by the combination of Sirolimus and Temsirolimus
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