Drug General Information (ID: DDIL1H904Y)
Drug Name			Tranylcypromine		Drug Info		Isoflurane		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidepressants				Anesthetics
Structure

Mechanism of Tranylcypromine-Isoflurane Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Tranylcypromine				Isoflurane
Mechanism		Increase the risk of hypotension or hypertension in combination with general anesthetics				General anesthetic
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Isoflurane and Tranylcypromine

Recommended Action
Management		The makers of MAOIs, both selective and nonselective, consider general anesthesia to be contraindicated in patients treated with MAOIs and recommend discontinuing MAOI therapy 10 to 14 days before elective surgery.

References
1	Product Information. Azilect (rasagiline). Teva Pharmaceuticals USA, North Wales, PA.
2	Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
3	Product Information. Nardil (phenelzine). Parke-Dvis, Morris Plains, NJ.