Drug General Information (ID: DDIKWND3ZX)
Drug Name			Hyoscyamine		Drug Info		Nitroglycerin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Vasodilator Agents
Structure

Mechanism of Hyoscyamine-Nitroglycerin Interaction (Severity Level: Minor)
Affecting drug dissolution Click to Show/Hide Mechanism Graph
Drug Name		Hyoscyamine				Nitroglycerin
Mechanism		Decrease the dissolution of sublingual nitroglycerin				Nitroglycerin
Key Mechanism Factor 1
		Factor Name		Salivary gland
		Factor Description		Sublingual administration requires the drug to be dissolved by saliva and then absorbed from the oral mucosa. The absorption of the drug may be decreased when saliva production is reduced.
Mechanism Description		Decreased dissolution of Nitroglycerin taken sublingually caused by Hyoscyamine

References
1	Product Information. Nitrostat (nitroglycerin). Parke-Davis, Morris Plains, NJ.