Drug General Information (ID: DDIKVZ1JE8)
Drug Name			Pralatrexate		Drug Info		Varicella Zoster Vaccine (Recombinant)		Drug Info
Drug Type		Small molecule				Vaccine
Therapeutic Class		Antimetabolites				Vaccine

Mechanism of Pralatrexate-Varicella Zoster Vaccine (Recombinant) Interaction (Severity Level: Major)
Antagonize the effect of vaccine/toxoid Click to Show/Hide Mechanism Graph
Drug Name		Pralatrexate				Varicella Zoster Vaccine (Recombinant)
Mechanism		Immunosuppressive effects				Vaccine or toxoid
Key Mechanism Factor 1
		Factor Name		Vaccine/toxoid
		Factor Description		The beneficial effects of the vaccine/toxinoid may be reduced, leading to a diminished or suboptimal immune response.
Mechanism Description		Antagonize the effect of Varicella Zoster Vaccine (Recombinant) when combined with Pralatrexate

Recommended Action
Management		In general, live attenuated vaccines should not be used in patients receiving immunosuppressive therapy or cancer chemotherapy. Vaccination should be deferred until after such therapy is discontinued and immune function has been restored, usually 4 to 12 weeks after stopping immunosuppressive therapy. A longer waiting period may be necessary following treatment with agents that have a prolonged elimination half-life (e.g., leflunomide, teriflunomide). Current local immunization guidelines should be consulted for recommendations.

References
1	Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998).
2	Product Information. Attenuvax (measles virus vaccine, live, attenuated). Merck &amp Co, Inc, West Point, PA.
3	Product Information. YF-Vax (yellow fever vaccine). sanofi pasteur, Swiftwater, PA.