Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIKLAH28J)
  Drug Name Thioridazine Drug Info Diethylpropion Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antipsychotic Agents Cns Stimulants
  Structure

 Mechanism of Thioridazine-Diethylpropion Interaction (Severity Level: Moderate)
     Antagonize the effect of dopaminergic agents Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Thioridazine Diethylpropion
      Mechanism Antidopaminergic effects
Dopamine receptor  Antagonist 		Dopaminergic effects
Dopamine transporter  Inhibitor
      Key Mechanism Factor 1
Factor Name Dopamine receptor Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
    Click to Show/Hide
      Key Mechanism Factor 2
Factor Name Dopamine transporter
×
Structure Sequence
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
Gene Name SLC6A3
Uniprot ID SC6A3_HUMAN
KEGG Pathway hsa:6531
Protein Family Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
Protein Function
Amine transporter (PubMed:1406597, PubMed:8302271, PubMed:15505207). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity).
    Click to Show/Hide
      Mechanism Description
  • Antagonize the effect of Diethylpropion when combined with Thioridazine 

Recommended Action
      Management Amphetamine, amphetamine derivatives, and other CNS stimulants should generally not be used, particularly for weight reduction, in patients treated with phenothiazines.

References
1 Achor MB, Extein I "Diet aids, mania, and affective illness" Am J Psychiatry 138 (1981): 392. [PMID: 7468847]
2 Angrist B, Lee HK, Gershon S "The antagonism of amphetamine-induced symptomatology by a neuroleptic." Am J Psychiatry 131 (1974): 817-9. [PMID: 4600629]
3 Casey JF, Hollister LE, Klett CJ, Lasky JJ, Caffey EM "Combined drug therapy of chronic schizophrenics." Am J Psychiatry 177 (1961): 997. [PMID: 13691268]
4 Chouinard G, Ghadirian AM, Jones BD "Death attributed to ventricular arrhythmia induced by thioridazine in combination with a single Contac*C capsule." Can Med Assoc J 119 (1978): 729-31. [PMID: 709472]
5 Cornelius JR, Soloff PH, Reynolds CF, 3d "Paranoia, homicidal behavior, and seizures associated with phenylpropanolamine." Am J Psychiatry 141 (1984): 120-1. [PMID: 6691429]
6 Dewsnap P, Libby G "A case of affective psychosis after routine use of proprietary cold remedy containing phenylpropanolamine" Hum Exp Toxicol 11 (1992): 295-6. [PMID: 1354981]
7 Dietz AJ, Jr "Amphetamine-like reactions to phenylpropanolamine." JAMA 245 (1981): 601-2. [PMID: 7452888]
8 Finton CK, Barton M, Chernow B "Possible adverse effects of phenylpropanolamine (diet pills) on sympathetic nervous system function--caveat emptor!" Mil Med 147 (1982): 1072. [PMID: 6817204]
9 Grieger TA, Clayton AH, Goyer PF "Affective disorder following use of phenylpropanolamine" Am J Psychiatry 147 (1990): 367-8. [PMID: 2309957]
10 Lake CR "Manic psychosis after coffee and phenylpropanolamine." Biol Psychiatry 30 (1991): 401-4. [PMID: 1912131]
11 Lake CR, Tenglin R, Chernow B, Holloway HC "Psychomotor stimulant-induced mania in a genetically predisposed patient: a review of the literature and report of a case." J Clin Psychopharmacol 3 (1983): 97-100. [PMID: 6341419]
12 Lambert MT "Paranoid psychoses after abuse of proprietary cold remedies." Br J Psychiatry 151: (1987): 548-50. [PMID: 3447673]
13 Markowitz JS, Patrick KS "Pharmacokinetic and pharmacodynamic drug interactions in the treatment of attention-deficit hyperactivity disorder." Clin Pharmacokinet 40 (2001): 753-72. [PMID: 11707061]
14 Marshall RD, Douglas CJ "Phenylpropanolamine-induced psychosis: potential predisposing factors." Gen Hosp Psychiatry 16 (1994): 358-60. [PMID: 7995508]
15 Modell W, Hussar AE "Failure of dextroamphetamine sulfate to incluence eating and sleeping patterns in obese schizophrenic patients." JAMA 193 (1965): 275-8. [PMID: 14310348]
16 Mueller SM "Neurologic complications of phenylpropanolamine use." Neurology 33 (1983): 650-2. [PMID: 6682504]
17 Norvenius G, Widerlov E, Lonnerholm G "Phenylpropanolamine and mental disturbances" Lancet 2 (1979): 1367-8. [PMID: 92706]
18 Product Information. Adderall (amphetamine-dextroamphetamine) Shire Richwood Pharmaceutical Company, Florence, KY.
19 Product Information. Cylert (pemoline). Abbott Pharmaceutical, Abbott Park, IL.
20 Product Information. Desoxyn (methamphetamine) Abbott Pharmaceutical, Abbott Park, IL.
21 Product Information. Dexedrine (dextroamphetamine) SmithKline Beecham, Philadelphia, PA.
22 Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
23 Product Information. Fastin (phentermine). SmithKline Beecham, Philadelphia, PA.
24 Product Information. Focalin (dexmethylphenidate). Mikart Inc, Atlanta, GA.
25 Product Information. Prelu-2 (phendimetrazine) Boehringer-Ingelheim, Ridgefield, CT.
26 Product Information. Ritalin (methylphenidate). Novartis Pharmaceuticals, East Hanover, NJ.
27 Product Information. Sanorex (mazindol) Novartis Pharmaceuticals, East Hanover, NJ.
28 Product Information. Tenuate (diethylpropion) Aventis Pharmaceuticals, Swiftwater, PA.
29 Product Information. Vyvanse (lisdexamfetamine). Shire US Inc, Florence, KY.
30 Reid AA "Pharmacological antagonism between chlorpromazine and phenmetrazine in mental hospital patients." Med J Aust 1 (1964): 187-8. [PMID: 14126355]
31 Schaffer CB, Pauli MW "Psychotic reaction caused by proprietary oral diet agents." Am J Psychiatry 137 (1980): 1256-7. [PMID: 7416278]
32 Sletten IW, Ognjanov V, Menendez S, Sundland D, El-Toumi A "Weight reduction with chlorphentermine and phenmetrazine in obese psychiatric patients during chlorpromazine therapy." Curr Ther Res Clin Exp 9 (1967): 570-5. [PMID: 4965506]
33 Stroe AE, Hall J, Amin F "Psychotic episode related to phenylpropanolamine and amantadine in a healthy female." Gen Hosp Psychiatry 17 (1995): 457-8. [PMID: 8714809]
34 Wharton BK "Nasal decongestants and paranoid psychosis." Br J Psychiatry 117 (1970): 439-40. [PMID: 4098187]