Drug General Information (ID: DDIKIBFG4H)
  Drug Name Insulin glargine Drug Info Phentolamine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antidiabetic Agents Antihypertensive Agents
  Structure

 Mechanism of Insulin glargine-Phentolamine Interaction (Severity Level: Minor)
     Increased risk of hypoglycemia Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Insulin glargine Phentolamine
      Mechanism Insulin Hypoglycemic effects
Increase the endogenous secretion of insulin 
      Key Mechanism Factor 1
Factor Name Hypoglycemia
Factor Description Hypoglycemia is a condition in which your blood sugar (glucose) level is below the standard range. It causes irregular or rapid heartbeat, pale skin, numbness of the lips, tongue or cheeks, and sweating.
      Mechanism Description
  • Increased risk of hypoglycemia by the combination of Insulin glargine and Phentolamine 

References
1 Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
2 Persson I, Larsen L "Serum insulin concentration after alpha-adrenergic blockade and secretin in diabetics." Acta Endocrinol (Copenh) 71 (1972): 331-7
3 Linde J, Deckert T "Increase of insulin concentration in maturity-onset diabetics by phentolamine (Regitine) infusion." Horm Metab Res 5 (1973): 391-5