Drug General Information (ID: DDIKDP1S3Q)
Drug Name			Dofetilide		Drug Info		Pimozide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Antipsychotic Agents
Structure

Mechanism of Dofetilide-Pimozide Interaction (Severity Level: Major)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Dofetilide				Pimozide
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Dofetilide and Pimozide

Recommended Action
Management		Coadministration of pimozide with other drugs that can prolong the QT interval is considered contraindicated.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
3	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
4	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".