Drug General Information (ID: DDIK9AWRZS)
Drug Name			Vardenafil		Drug Info		Procainamide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Impotence Agents				Antiarrhythmic Agents
Structure

Mechanism of Vardenafil-Procainamide Interaction (Severity Level: Major)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Vardenafil				Procainamide
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Vardenafil and Procainamide

Recommended Action
Management		Patients treated with class IA (e.g., disopyramide, quinidine, procainamide) or class III (e.g., amiodarone, dofetilide, ibutilide, sotalol) antiarrhythmic agents, should avoid using vardenafil.

References
1	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.