Details of Drug-Drug Interaction
| Drug General Information (ID: DDIK236NYW) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Vardenafil | Drug Info | Amiodarone | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Impotence Agents | Antiarrhythmic Agents | |||||||
| Structure | |||||||||
| Mechanism of Vardenafil-Amiodarone Interaction (Severity Level: Major) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Vardenafil | Amiodarone | |||||||
| Mechanism | Prolong QT interval | Prolong QT interval | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | QT interval | ||||||||
| Factor Description | Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Patients treated with class IA (e.g., disopyramide, quinidine, procainamide) or class III (e.g., amiodarone, dofetilide, ibutilide, sotalol) antiarrhythmic agents, should avoid using vardenafil. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. Levitra (vardenafil). Bayer, West Haven, CT. | ||||||||||||||||||