Drug General Information (ID: DDIK1AR3HX)
Drug Name			Metolazone		Drug Info		Mepenzolate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Parasympatholytics
Structure

Mechanism of Metolazone-Mepenzolate Interaction (Severity Level: Minor)
Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Drug Name		Metolazone				Mepenzolate
Mechanism		Absorption is influenced by gastrointestinal motility				Decrease gastrointestinal motility
Key Mechanism Factor 1
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Metolazone due to GI dynamics variation caused by Mepenzolate

References
1	Beermann B, Groschinsky-Grind M "Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline." Eur J Clin Pharmacol 13 (1978): 385-7. [PMID: 668798]
2	Shukla UA, Pittman KA, Barbhaiya RH. Pharmacokinetic interactions of cefprozil with food, propantheline, metoclopramide, and probenecid in healthy volunteers.?J Clin Pharmacol. 1992;32(8):725-731. [PMID: 1487562]