Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIJX7N0TG)
  Drug Name Tryptophan Drug Info Ozanimod Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antidepressants Selective Immunosuppressants
  Structure

 Mechanism of Tryptophan-Ozanimod Interaction (Severity Level: Moderate)
     Additive serotonergic effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Tryptophan Ozanimod
      Mechanism Serotonergic effects
5-HT receptor  Agonist 		Serotonergic effects
Monoamine oxidase-B selective  Inhibitor
      Key Mechanism Factor 1
Factor Name 5-HT receptor Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
    Click to Show/Hide
      Key Mechanism Factor 2
Factor Name Monoamine oxidase type B
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Structure Sequence
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
Gene Name MAOB
Uniprot ID AOFB_HUMAN
KEGG Pathway hsa:4129
Protein Family Flavin monoamine oxidase family
Protein Function
Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:11134050, PubMed:8665924, PubMed:8316221, PubMed:11049757, PubMed:20493079). Preferentially degrades benzylamine and phenylethylamine (PubMed:11134050, PubMed:8665924, PubMed:8316221, PubMed:11049757, PubMed:20493079).
    Click to Show/Hide
      Mechanism Description
  • Additive serotonergic effects by the combination of Tryptophan and Ozanimod 

Recommended Action
      Management Until more information is available, concomitant use of ozanimod with serotonergic agents should be avoided when possible. Blood pressure and other vitals should be monitored if coadministration is required.

References
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40 Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
41 Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
42 Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
43 Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
44 Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
45 Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
46 Product Information. Imitrex (sumatriptan). Glaxo Wellcome, Research Triangle Park, NC.
47 Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
48 Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
49 Product Information. Manerix (moclobemide). Hoffmann-La Roche Limited, Mississauga, IA.
50 Product Information. Maxalt (rizatriptan). Merck & Co, Inc, West Point, PA.
51 Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
52 Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
53 Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
54 Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
55 Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
56 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
57 Product Information. Zoloft (sertraline). Roerig Division, New York, NY.
58 Product Information. Zomig (zolmitriptan). Zeneca Pharmaceuticals, Wilmington, DE.
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