Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIJTULFG8)
  Drug Name Betamethasone Drug Info Eprosartan Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiinflammatory Agents Antihypertensive Agents
  Structure

 Mechanism of Betamethasone-Eprosartan Interaction (Severity Level: Moderate)
     Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Betamethasone Eprosartan
      Mechanism Hypertensive effects
Induction of sodium and fluid retention  		Antihypertensive agent
Angiotensin II receptor  Antagonist
      Key Mechanism Factor 1
Factor Name Angiotensin II receptor Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.; (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.
    Click to Show/Hide
      Mechanism Description
  • Antagonize the effect of Betamethasone when combined with Eprosartan 

Recommended Action
      Management Patients on prolonged (i.e., longer than about a week) or high-dose corticosteroid therapy should have blood pressure, electrolyte levels, and body weight monitored regularly, and be observed for the development of edema and congestive heart failure. The dosages of antihypertensive medications may require adjustment.

References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 Multum Information Services, Inc. Expert Review Panel.