Details of Drug-Drug Interaction
| Drug General Information (ID: DDIJRSPBU2) | |||||||||
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| Drug Name | Temsirolimus | Drug Info | Givosiran | Drug Info | |||||
| Drug Type | Small molecule | Small interfering RNA | |||||||
| Therapeutic Class | Antineoplastics/Mtor Inhibitors | Metabolic Agents | |||||||
| Structure | |||||||||
| Mechanism of Temsirolimus-Givosiran Interaction (Severity Level: Major) | |||||||||
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| Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Temsirolimus | Givosiran | |||||||
| Mechanism | Nephrotoxicity | Nephrotoxicity | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Nephrotoxicity | ||||||||
| Factor Description | The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Caution is advised when macrolide immunosuppressants is used in patients who have recently received or are receiving treatment with other potentially nephrotoxic drugs (e.g., aminoglycosides polypeptide, glycopeptide, and polymyxin antibiotics amphotericin B adefovir cidofovir tenofovir foscarnet cisplatin cyclosporine deferasirox gallium nitrate lithium mesalamine intravenous bisphosphonates intravenous pentamidine high intravenous dosages of methotrexate high dosages and/or chronic use of nonsteroidal anti-inflammatory agents). Renal function should be closely monitored both during and after discontinuation of therapy. Patients should be advised to seek medical attention if they experience symptoms that may indicate nephrotoxicity such as decreased urine output, sudden weight gain, fluid retention, edema, or shortness of breath. | ||||||||