Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIJQFSZD5)
  Drug Name Vancomycin Drug Info Plazomicin Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiinfective Agents Aminoglycosides//Antibiotics
  Structure

 Mechanism of Vancomycin-Plazomicin Interaction (Severity Level: Moderate)
     Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Vancomycin Plazomicin
      Mechanism Nephrotoxicity Nephrotoxicity
      Key Mechanism Factor 1
Factor Name Nephrotoxicity
Factor Description The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
      Mechanism Description
  • Increased risk of nephrotoxicity by the combination of Vancomycin and Plazomicin 

Recommended Action
      Management If these drugs must be used together, renal function and serum drug concentrations should be monitored.

References
1 Dean RP, Wagner DJ, Tolpin MD "Vancomycin/aminoglycoside nephrotoxicity." J Pediatr 106 (1985): 861-2. [PMID: 3998936]
2 Downs NJ, Neihart RE, Dolezal JM, Hodges GR "Mild nephrotoxicity associated with vancomycin use." Arch Intern Med 149 (1989): 1777-81. [PMID: 2764651]
3 Farber BF, Moellering RC Jr "Retrospective study of the toxicity of preparations of vancomycin from 1974 to 1981." Antimicrob Agents Chemother 23 (1983): 138-41. [PMID: 6219616]
4 Odio C, McCracken GH, Nelson JD "Nephrotoxicity associated with vancomycin-aminoglycoside therapy in four children." J Pediatr 105 (1984): 491-2. [PMID: 6470874]
5 Pauly DJ, Musa DM, Lestico MR, Lindstrom MJ, Hetsko CM "Risk of nephrotoxicity with combination vancomycin-aminoglycoside antibiotic therapy." Pharmacotherapy 10 (1990): 378-82. [PMID: 2287556]
6 Sorrell TC, Collignon PJ "A prospective study of adverse reactions associated with vancomycin therapy." J Antimicrob Chemother 16 (1985): 235-41. [PMID: 3934126]