Drug General Information (ID: DDIJNS5WYA)
Drug Name			Amiodarone		Drug Info		Remimazolam		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Benzodiazepines
Structure

Mechanism of Amiodarone-Remimazolam Interaction (Severity Level: Minor)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Amiodarone				Remimazolam
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Amiodarone and Remimazolam

References
1	Kerin NZ, Aragon E, Faitel K, Frumin H, Rubenfire M "Long-term efficacy and toxicity of high- and low-dose amiodarone regimens." J Clin Pharmacol 29 (1989): 418-23. [PMID: 2661600]
2	Nolan PE, Marcus FI, Karol MD, Hoyer GL, Gear K "Effect of phenytoin on the clinical pharmacokinetics of amiodarone." J Clin Pharmacol 30 (1990): 1112-9. [PMID: 2273084]
3	Product Information. Niravam (alprazolam). Schwarz Pharma, Mequon, WI.
4	Product Information. Xanax (alprazolam). Pharmacia and Upjohn, Kalamazoo, MI.
5	Product Information. Xanax XR (alprazolam). Pfizer U.S. Pharmaceuticals Group, New York, NY.
6	Wilson JS, Podrid PJ "Side effects from amiodarone." Am Heart J 121 (1991): 158-71. [PMID: 1985357]