Details of Drug-Drug Interaction
| Drug General Information (ID: DDIJNFRHIS) | |||||||||
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| Drug Name | Valproic acid | Drug Info | Salicylic acid (sodium) | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Anticonvulsants | Antiinflammatory Agents | |||||||
| Structure | |||||||||
| Mechanism of Valproic acid-Salicylic acid (sodium) Interaction (Severity Level: Moderate) | |||||||||
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| Competitive binding of plasma proteins Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Valproic acid | Salicylic acid (sodium) | |||||||
| Mechanism | Competition for plasma protein binding sites | Competition for plasma protein binding sites | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Plasma protein binding | ||||||||
| Factor Description | Plasma protein binding refers to the degree of binding of a drug to proteins in the blood, and the lower the degree of binding, the more efficiently the drug can cross cell membranes or diffuse. Plasma protein binding alters the distribution and therapeutic characteristics of the drugs. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Small single doses of salicylates are unlikely to cause significant effects. However, patients who take large doses of salicylates or over a prolonged period of time should be closely monitored for clinical and laboratory evidence of valproate toxicity and hepatotoxicity. Free fraction of valproate may be particularly helpful in detecting this interaction. Patients should be advised to notify their physician if they experience possible symptoms of toxicity (e.g., malaise, weakness, lethargy, drowsiness, nausea, vomiting, or abdominal pain). | ||||||||