Drug General Information (ID: DDIJG7L8SK)
Drug Name			Testolactone		Drug Info		Ethinylestradiol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Estrogens
Structure

Mechanism of Testolactone-Ethinylestradiol Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Testolactone				Ethinylestradiol
Mechanism		Aromatase inhibitor				Decrease the therapeutic effect of aromatase inhibitor
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Testolactone when combined with Ethinylestradiol

Recommended Action
Management		Use of estrogen-containing products should be avoided during aromatase inhibitor therapy.

References
1	Product Information. Aromasin (exemestane) Pharmacia &amp Upjohn, Kalamazoo, MI.
2	Product Information. Femara (letrozole). Novartis Pharmaceuticals, East Hanover, NJ.
3	Product Information. Arimidex (anastrozole). Zeneca Pharmaceuticals, Wilmington, DE.