Drug General Information (ID: DDIJ542ZYS)
Drug Name			Epirubicin		Drug Info		Candida albicans		Drug Info
Drug Type		Small molecule				Allergenics
Therapeutic Class		Antineoplastics				Allergy Test
Structure

Mechanism of Epirubicin-Candida albicans Interaction (Severity Level: Moderate)
Diminish the response to diagnostic skin test antigens Click to Show/Hide Mechanism Graph
Drug Name		Epirubicin				Candida albicans
Mechanism		Immunosuppressive effects				Diagnostic skin test antigens
Key Mechanism Factor 1
		Factor Name		Diagnostic skin test antigens
		Factor Description		The efficacy of diagnostic skin test antigens may be reduced, leading to falsely insignificant or false-negative results may occur in such patients.
Mechanism Description		Reduced reactions to diagnostic skin test antigens for Candida albicans when combined with Epirubicin

Recommended Action
Management		Clinicians should be aware of the potential for falsely insignificant or false-negative results when administering diagnostic skin test antigens to patients treated with immunosuppressive agents.

References
1	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
2	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
3	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.