Details of Drug-Drug Interaction
| Drug General Information (ID: DDIJ1SRHVB) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Delavirdine | Drug Info | Ranitidine (bismuth citrate) | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Anti-Hiv Agents | Antiulcer Agents | |||||||
| Structure | |||||||||
| Mechanism of Delavirdine-Ranitidine (bismuth citrate) Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Altered gastric pH Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Delavirdine | Ranitidine (bismuth citrate) | |||||||
| Mechanism | Gastric pH sensitive | Gastric alkalinizer | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Gastric pH | ||||||||
| Factor Description | The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | While the clinical significance of this potential interaction is unknown, the manufacturer recommends against the chronic use of these drugs with delavirdine due to the risk of treatment failure and emergence of drug resistance associated with subtherapeutic levels of delavirdine. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. Rescriptor (delavirdine). Pharmacia and Upjohn, Kalamazoo, MI. | ||||||||||||||||||